Analysis of effects of MCB3681, the antibacterially active substance of prodrug MCB3837, on human resident microflora as proof of principle.
Clin Microbiol Infect
; 21(8): 767.e1-4, 2015 Aug.
Article
in En
| MEDLINE
| ID: mdl-26047854
ABSTRACT
The water-soluble prodrug MCB3837 is rapidly converted to MCB3681, active against Gram-positive bacterial species, after intravenous infusion. The aim of this study was to prove the principle that MCB3681 is efficacious in vivo by demonstrating its effect on the resident microflora or colonizers of the human skin, nose, oropharynx and intestine. MCB3837 was infused at a daily dose of 6 mg/kg for 5 days. MCB3681 was active against clostridia, bifidobacteria, lactobacilli, enterococci and Staphylococcus aureus, thus proving the principle that MCB3681 is antibacterially efficacious in vivo without affecting the Gram-negative microflora.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Microbiota
/
Gram-Positive Bacteria
/
Anti-Bacterial Agents
Limits:
Humans
/
Male
Language:
En
Journal:
Clin Microbiol Infect
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Year:
2015
Type:
Article