Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines.

Chang, Tammy T; Spurlock, Sandra M; Candelario, Tara Lynne T; Grenon, S Marlene; Hughes-Fulford, Millie

Chang, Tammy T; Spurlock, Sandra M; Candelario, Tara Lynne T; Grenon, S Marlene; Hughes-Fulford, Millie.

Affiliation

Chang TT; *Department of Surgery and Department of Medicine, University of California, San Franscisco, San Francisco, California, USA; and Northern California Institute for Research and Education, San Francisco, California, USA tammy.chang@ucsf.edu.
Spurlock SM; *Department of Surgery and Department of Medicine, University of California, San Franscisco, San Francisco, California, USA; and Northern California Institute for Research and Education, San Francisco, California, USA.
Candelario TL; *Department of Surgery and Department of Medicine, University of California, San Franscisco, San Francisco, California, USA; and Northern California Institute for Research and Education, San Francisco, California, USA.
Grenon SM; *Department of Surgery and Department of Medicine, University of California, San Franscisco, San Francisco, California, USA; and Northern California Institute for Research and Education, San Francisco, California, USA.
Hughes-Fulford M; *Department of Surgery and Department of Medicine, University of California, San Franscisco, San Francisco, California, USA; and Northern California Institute for Research and Education, San Francisco, California, USA.

FASEB J ; 29(10): 4122-32, 2015 Oct.

Article in En | MEDLINE | ID: mdl-26085131

Subject(s)

Antigens/immunology; CD4-Positive T-Lymphocytes/immunology; Cytokines/immunology; Immune Tolerance/immunology; Inflammation Mediators/immunology; Space Flight; Adjuvants, Immunologic/pharmacology; Adoptive Transfer; Animals; Antigens/pharmacology; CD4-Positive T-Lymphocytes/metabolism; Cell Division/drug effects; Cell Division/immunology; Cells, Cultured; Cytokines/metabolism; Female; Flow Cytometry; Immune Tolerance/drug effects; Inflammation Mediators/metabolism; Interferon-gamma/immunology; Interferon-gamma/metabolism; Interleukin-17/immunology; Interleukin-17/metabolism; Lipid A/analogs & derivatives; Lipid A/immunology; Lipid A/pharmacology; Mice, Congenic; Mice, Inbred C57BL; Ovalbumin/immunology; Ovalbumin/pharmacology; Receptors, Antigen, T-Cell/immunology; Receptors, Antigen, T-Cell/metabolism; Time Factors

Key words

T-cell memory; T-cell tolerance; inflammation; microgravity; transgenic model

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Space Flight / CD4-Positive T-Lymphocytes / Cytokines / Inflammation Mediators / Immune Tolerance / Antigens Type of study: Prognostic_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2015 Type: Article Affiliation country: United States

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