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Tracking ongoing cognition in individuals using brief, whole-brain functional connectivity patterns.
Gonzalez-Castillo, Javier; Hoy, Colin W; Handwerker, Daniel A; Robinson, Meghan E; Buchanan, Laura C; Saad, Ziad S; Bandettini, Peter A.
Affiliation
  • Gonzalez-Castillo J; Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892; javier.gonzalez-castillo@nih.gov.
  • Hoy CW; Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892; Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720;
  • Handwerker DA; Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892;
  • Robinson ME; Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892; Veterans Affairs Boston Healthcare System, Boston, MA 02130;
  • Buchanan LC; Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892;
  • Saad ZS; Statistical and Scientific Computing Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892;
  • Bandettini PA; Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892; Functional MRI Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892.
Proc Natl Acad Sci U S A ; 112(28): 8762-7, 2015 Jul 14.
Article in En | MEDLINE | ID: mdl-26124112
ABSTRACT
Functional connectivity (FC) patterns in functional MRI exhibit dynamic behavior on the scale of seconds, with rich spatiotemporal structure and limited sets of whole-brain, quasi-stable FC configurations (FC states) recurring across time and subjects. Based on previous evidence linking various aspects of cognition to group-level, minute-to-minute FC changes in localized connections, we hypothesized that whole-brain FC states may reflect the global, orchestrated dynamics of cognitive processing on the scale of seconds. To test this hypothesis, subjects were continuously scanned as they engaged in and transitioned between mental states dictated by tasks. FC states computed within windows as short as 22.5 s permitted robust tracking of cognition in single subjects with near perfect accuracy. Accuracy dropped markedly for subjects with the lowest task performance. Spatially restricting FC information decreased accuracy at short time scales, emphasizing the distributed nature of whole-brain FC dynamics, beyond univariate magnitude changes, as valuable markers of cognition.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Cognition Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2015 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Cognition Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2015 Type: Article