Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications.

Arif, S M; Geethanandan, K; Mishra, P; Surolia, A; Varshney, U; Vijayan, M

Arif, S M; Geethanandan, K; Mishra, P; Surolia, A; Varshney, U; Vijayan, M.

Affiliation

Arif SM; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
Geethanandan K; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
Mishra P; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
Surolia A; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
Varshney U; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India.
Vijayan M; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.

Acta Crystallogr D Biol Crystallogr ; 71(Pt 7): 1514-27, 2015 Jul.

Article in En | MEDLINE | ID: mdl-26143923

Subject(s)

Mycobacterium tuberculosis/enzymology; Uracil-DNA Glycosidase/chemistry; Uracil-DNA Glycosidase/metabolism; Uracil/metabolism; Binding Sites; Citric Acid/metabolism; Crystallography, X-Ray; Humans; Models, Molecular; Mycobacterium tuberculosis/chemistry; Mycobacterium tuberculosis/metabolism; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Uracil/analogs & derivatives

Key words

DNA repair; conformational selection; excision repair; ligand binding; molecular plasticity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uracil / Uracil-DNA Glycosidase / Mycobacterium tuberculosis Limits: Humans Language: En Journal: Acta Crystallogr D Biol Crystallogr Year: 2015 Type: Article Affiliation country: India

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