Adaptive sample size modification in clinical trials: start small then ask for more?

Jennison, Christopher; Turnbull, Bruce W

Jennison, Christopher; Turnbull, Bruce W.

Affiliation

Jennison C; Department of Mathematical Sciences, University of Bath, Bath, U.K.
Turnbull BW; School of Operations Research and Information Engineering, Cornell University, Ithaca, NY, U.S.A.

Stat Med ; 34(29): 3793-810, 2015 Dec 20.

Article in En | MEDLINE | ID: mdl-26172385

Subject(s)

Bias; Clinical Trials as Topic/statistics & numerical data; Sample Size; Antipsychotic Agents/administration & dosage; Clinical Trials as Topic/methods; Clinical Trials as Topic/standards; Clinical Trials, Phase III as Topic/methods; Clinical Trials, Phase III as Topic/standards; Clinical Trials, Phase III as Topic/statistics & numerical data; Humans; Research Design/statistics & numerical data; Schizophrenia/drug therapy

Key words

adaptive design; clinical trial; group sequential test; optimal design; promising zone; sample size re-estimation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bias / Clinical Trials as Topic / Sample Size Type of study: Prognostic_studies Limits: Humans Language: En Journal: Stat Med Year: 2015 Type: Article Affiliation country: United kingdom

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