A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.

Rempel, Eugen; Hoelting, Lisa; Waldmann, Tanja; Balmer, Nina V; Schildknecht, Stefan; Grinberg, Marianna; Das Gaspar, John Antony; Shinde, Vaibhav; Stöber, Regina; Marchan, Rosemarie; van Thriel, Christoph; Liebing, Julia; Meisig, Johannes; Blüthgen, Nils; Sachinidis, Agapios; Rahnenführer, Jörg; Hengstler, Jan G; Leist, Marcel

Rempel, Eugen; Hoelting, Lisa; Waldmann, Tanja; Balmer, Nina V; Schildknecht, Stefan; Grinberg, Marianna; Das Gaspar, John Antony; Shinde, Vaibhav; Stöber, Regina; Marchan, Rosemarie; van Thriel, Christoph; Liebing, Julia; Meisig, Johannes; Blüthgen, Nils; Sachinidis, Agapios; Rahnenführer, Jörg; Hengstler, Jan G; Leist, Marcel.

Affiliation

Rempel E; Department of Statistics, TU Dortmund University, 44139, Dortmund, Germany.

Arch Toxicol ; 89(9): 1599-618, 2015 Sep.

Article in En | MEDLINE | ID: mdl-26272509

Subject(s)

Histone Deacetylase Inhibitors/toxicity; Neural Plate/drug effects; Pluripotent Stem Cells/drug effects; Transcriptome; Gene Expression Profiling; Humans; Neural Plate/metabolism; Oligonucleotide Array Sequence Analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pluripotent Stem Cells / Neural Plate / Histone Deacetylase Inhibitors / Transcriptome Type of study: Prognostic_studies Limits: Humans Language: En Journal: Arch Toxicol Year: 2015 Type: Article Affiliation country: Germany

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