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Determination of in Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics.
Murphy, Dennis J; Ou, Yangsi; Euler, Danielle H; Wessner, Keith; Adamski, Sharon; Luo, Bin; Wesolowski, Gregg A; Vogel, Robert; Glantschnig, Helmut; Lubbers, Laura S; Carroll, Stephen S; Lai, Ming-Tain.
Affiliation
  • Murphy DJ; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Ou Y; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Euler DH; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Wessner K; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Adamski S; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Luo B; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Wesolowski GA; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Vogel R; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Glantschnig H; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Lubbers LS; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Carroll SS; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
  • Lai MT; In Vitro Pharmacology, ‡Bone Biology, and §In Vivo Pharmacology, Merck Research Laboratories , West Point, Pennsylvania 19486, United States.
J Am Chem Soc ; 137(35): 11230-3, 2015 Sep 09.
Article in En | MEDLINE | ID: mdl-26301491
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Cathepsin K Limits: Animals Language: En Journal: J Am Chem Soc Year: 2015 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Cathepsin K Limits: Animals Language: En Journal: J Am Chem Soc Year: 2015 Type: Article Affiliation country: United States