Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis.
Genet Mol Res
; 14(3): 9163-70, 2015 Aug 07.
Article
in En
| MEDLINE
| ID: mdl-26345849
ABSTRACT
The aim of this study was to investigate the correlation between the A1166C polymorphism in the angiotensin II type 1 receptor (AT1R) gene and heart failure (HF) risk using metaanalysis. The PubMed database was searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using the STATA 12.0 software. The results of the metaanalysis showed no significant association between the AT1R A1166C polymorphism and HF risk (AA vs CC OR = 0.72, 95%CI = 0.31-1.68; AA vs AC OR = 0.78, 95%CI = 0.52-1.18; dominant model OR = 1.37, 95%CI = 0.92-2.04; recessive model OR = 0.73, 95%CI = 0.30-1.75). In the subgroup analysis by ethnicity, the results also showed no significant association between A1166C polymorphism and susceptibility to HF in both Caucasian and Asian populations. In conclusion, this meta-analysis suggests that the A1166C polymorphism in AT1R may not be associated with susceptibility to HF. Further large and well-designed studies are needed to confirm these conclusions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
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Receptor, Angiotensin, Type 1
/
Genetic Association Studies
/
Heart Failure
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Genet Mol Res
Journal subject:
BIOLOGIA MOLECULAR
/
GENETICA
Year:
2015
Type:
Article
Affiliation country:
China