Alleviating effect of Mallotus roxburghianus in heat-induced testicular dysfunction in Wistar rats.
Pharm Biol
; 54(5): 905-18, 2016.
Article
in En
| MEDLINE
| ID: mdl-26459670
ABSTRACT
CONTEXT Hyperthermia causes detrimental effects on the testes leading to fertility problems. Mallotus roxbhurghianus Muell. Arg. (Euphorbiaceae) is used in traditional medicine and possesses antioxidant property. However, the mechanisms remain unknown in the context of alleviative action of M. roxburghianus against heat stress. OBJECTIVE:
The objective of this study was to demonstrate the alleviating activity of M. roxburghianus and its mechanism in scrotal hyperthermia. MATERIALS ANDMETHODS:
Scrotal hyperthermia experiments were performed in three groups (n = 7 per group) consisting of (i) the control group (C) maintained at 22 °C for 30 min, (ii) the heat stress-induced group (HS), and (iii) the heat stress-induced M. roxburghianus-treated group (HSM - 400 mg/kg each) in a thermostatically controlled water bath at 43 °C for 30 min. Subsequent to the heat treatment HS group, rats were treated with saline p.o and methanol extract of M. roxburghianus was administered to the rats of HSM group along with their standard food for 14 d. Scrotal hyperthermic effects were evaluated.RESULTS:
Scrotal hyperthermia significantly (p < 0.0001) elevated malondialdehyde levels while decreasing the body and testes weights, serum testosterone, and antioxidant enzyme levels due to oxidative stress. Disorganisation of seminiferous tubules and arrest of spermatogenesis were observed in the HS group. The administration of methanol extract of M. roxburghianus (400 mg/kg) for 14 d after heat treatment significantly suppressed the lipid peroxidation, restored the antioxidant enzyme and testosterone levels, revived the spermatogenesis, and increased the cell proliferation activity in the HSM group. DISCUSSION ANDCONCLUSION:
The methanol extract of M. roxburghianus accelerates testicular recovery from the damaging influence of hyperthermia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Testis
/
Plant Extracts
/
Mallotus Plant
/
Hot Temperature
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Pharm Biol
Year:
2016
Type:
Article
Affiliation country:
India