Synthesis and Characterization of a Novel Mycophenolic Acid-Quinic Acid Conjugate Serving as Immunosuppressant with Decreased Toxicity.

Peng, Yang; Dong, Yuxiang; Mahato, Ram I

Peng, Yang; Dong, Yuxiang; Mahato, Ram I.

Affiliation

Peng Y; Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198-6025, United States.
Dong Y; Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198-6025, United States.
Mahato RI; Department of Pharmaceutical Sciences, University of Nebraska Medical Center , Omaha, Nebraska 68198-6025, United States.

Mol Pharm ; 12(12): 4445-53, 2015 Dec 07.

Article in En | MEDLINE | ID: mdl-26529468

Subject(s)

Immunosuppressive Agents/chemistry; Immunosuppressive Agents/pharmacology; Mycophenolic Acid/chemistry; Mycophenolic Acid/pharmacology; Quinic Acid/chemistry; Quinic Acid/pharmacology; Animals; Apoptosis/drug effects; Caspase 3/metabolism; Cell Line; Cell Proliferation/drug effects; Down-Regulation/drug effects; Humans; Insulin-Secreting Cells/drug effects; Insulin-Secreting Cells/metabolism; Lymphocyte Activation/drug effects; Lymphocytes/drug effects; Lymphocytes/metabolism; NF-kappa B/metabolism; Rats

Key words

caspase-3; immunosuppressant; mycophenolic acid; quinic acid; ß cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinic Acid / Immunosuppressive Agents / Mycophenolic Acid Limits: Animals / Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2015 Type: Article Affiliation country: United States

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