The multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximal tubules.

Martínez-Guerrero, L J; Evans, K K; Dantzler, W H; Wright, S H

Martínez-Guerrero, L J; Evans, K K; Dantzler, W H; Wright, S H.

Affiliation

Martínez-Guerrero LJ; Department of Physiology, College of Medicine, University of Arizona, Tucson, Arizona.
Evans KK; Department of Physiology, College of Medicine, University of Arizona, Tucson, Arizona.
Dantzler WH; Department of Physiology, College of Medicine, University of Arizona, Tucson, Arizona.
Wright SH; Department of Physiology, College of Medicine, University of Arizona, Tucson, Arizona shwright@email.arizona.edu.

Am J Physiol Renal Physiol ; 310(1): F57-67, 2016 Jan 01.

Article in En | MEDLINE | ID: mdl-26538438

Subject(s)

Kidney Tubules, Proximal/metabolism; Organic Cation Transport Proteins/metabolism; Renal Elimination; Renal Reabsorption; 1-Methyl-4-phenylpyridinium/metabolism; 4-Chloro-7-nitrobenzofurazan/analogs & derivatives; 4-Chloro-7-nitrobenzofurazan/metabolism; Animals; CHO Cells; Cricetulus; Endosomes/metabolism; Fluorescent Dyes/metabolism; Kinetics; Male; Microscopy, Fluorescence; Organic Cation Transport Proteins/genetics; Organic Cation Transporter 2; Quaternary Ammonium Compounds/metabolism; Rabbits; Transfection; Vacuolar Proton-Translocating ATPases/metabolism

Key words

multidrug and toxin extruder 1; organic cation secretion; proximal tubule; transport

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organic Cation Transport Proteins / Renal Reabsorption / Renal Elimination / Kidney Tubules, Proximal Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2016 Type: Article

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