[The role of long non-coding RNAs in hematologic malignancies].
Yi Chuan
; 37(11): 1095-104, 2015 11.
Article
in Zh
| MEDLINE
| ID: mdl-26582523
ABSTRACT
With the rapid development of molecular biology technology, researchers have got much deeper understanding of the role of long non-coding RNA (lncRNA). It is not only indispensable for biological processes, but also plays an important role in human diseases especially in tumor. Previous studies have shown that a variety of lncRNAs are closely associated with hematologic malignancies. These lncRNAs are involved in diseases through diverse functions including affecting the expression of tumor suppressor gene p15, regulating p53 protein function, and interacting with miRNAs. In this review, we summarize the hematological tumor-associated lncRNAs and focus on p15, p53 and miRNA-related lncRNAs as well as the role of their interaction in hematological malignancies, which may provide a comprehensive understanding of the role of hematological tumor-associated lncRNAs and some insights for research, diagnosis and treatment of hematologic malignancies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hematologic Neoplasms
/
RNA, Long Noncoding
Limits:
Humans
Language:
Zh
Journal:
Yi Chuan
Journal subject:
GENETICA
Year:
2015
Type:
Article
Affiliation country:
China