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CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo.
Rossi, Mario; Ruiz de Azua, Inigo; Barella, Luiz F; Sakamoto, Wataru; Zhu, Lu; Cui, Yinghong; Lu, Huiyan; Rebholz, Heike; Matschinsky, Franz M; Doliba, Nicolai M; Butcher, Adrian J; Tobin, Andrew B; Wess, Jürgen.
Affiliation
  • Rossi M; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Ruiz de Azua I; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Barella LF; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Sakamoto W; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Zhu L; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Cui Y; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Lu H; Mouse Transgenic Core Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Rebholz H; Sophie Davis School of Biomedical Education, The City College of New York, New York, NY 10031;
  • Matschinsky FM; Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104;
  • Doliba NM; Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104;
  • Butcher AJ; Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, United Kingdom.
  • Tobin AB; Medical Research Council Toxicology Unit, University of Leicester, Leicester LE1 9HN, United Kingdom.
  • Wess J; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; jurgenw@helix.nih.gov.
Proc Natl Acad Sci U S A ; 112(49): E6818-24, 2015 Dec 08.
Article in En | MEDLINE | ID: mdl-26598688
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Muscarinic M3 / Casein Kinase II / Insulin Limits: Animals / Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2015 Type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Muscarinic M3 / Casein Kinase II / Insulin Limits: Animals / Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2015 Type: Article