Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma.

Wong, Pok Fai; Gall, Margaret G; Bachovchin, William W; McCaughan, Geoffrey W; Keane, Fiona M; Gorrell, Mark D

Wong, Pok Fai; Gall, Margaret G; Bachovchin, William W; McCaughan, Geoffrey W; Keane, Fiona M; Gorrell, Mark D.

Affiliation

Wong PF; Centenary Institute of Cancer Medicine and Cell Biology, Sydney Medical School, The University of Sydney, NSW 2006, Australia.
Gall MG; Centenary Institute of Cancer Medicine and Cell Biology, Sydney Medical School, The University of Sydney, NSW 2006, Australia.
Bachovchin WW; Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
McCaughan GW; Centenary Institute of Cancer Medicine and Cell Biology, Sydney Medical School, The University of Sydney, NSW 2006, Australia.
Keane FM; Centenary Institute of Cancer Medicine and Cell Biology, Sydney Medical School, The University of Sydney, NSW 2006, Australia.
Gorrell MD; Centenary Institute of Cancer Medicine and Cell Biology, Sydney Medical School, The University of Sydney, NSW 2006, Australia. Electronic address: m.gorrell@centenary.usyd.edu.au.

Peptides ; 75: 80-95, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26621486

Subject(s)

Gelatinases/chemistry; Liver Cirrhosis/metabolism; Membrane Proteins/chemistry; Neuropeptide Y/chemistry; Receptors, Neuropeptide Y/metabolism; Serine Endopeptidases/chemistry; Animals; Carcinoma, Hepatocellular/metabolism; Case-Control Studies; Dipeptidyl Peptidase 4/blood; Endopeptidases; Gelatinases/physiology; Humans; Kinetics; Liver/metabolism; Liver Neoplasms/metabolism; Membrane Proteins/physiology; Mice, Inbred C57BL; Mice, Knockout; Protease Inhibitors/chemistry; Proteolysis; Serine Endopeptidases/physiology; Species Specificity; Substrate Specificity

Key words

Cancer; Dipeptidyl peptidase; Fibroblast activation protein; Kallikrein; Liver disease; Protease substrates

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptide Y / Serine Endopeptidases / Receptors, Neuropeptide Y / Gelatinases / Liver Cirrhosis / Membrane Proteins Type of study: Observational_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Peptides Year: 2016 Type: Article Affiliation country: Australia

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