A gateway to the brain: shuttles for brain delivery of macromolecules.

Webster, Carl I; Stanimirovic, Danica B

Webster, Carl I; Stanimirovic, Danica B.

Affiliation

Webster CI; Antibody Discovery & Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK.
Stanimirovic DB; Human Health Therapeutics Portfolio, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada.

Ther Deliv ; 6(12): 1321-4, 2015.

Article in En | MEDLINE | ID: mdl-26652278

Subject(s)

Brain/metabolism; Macromolecular Substances/metabolism; Blood-Brain Barrier/metabolism; Drug Carriers/chemistry; Drug Carriers/metabolism; Humans; Macromolecular Substances/chemistry; Transcytosis/physiology

Key words

bispecific antibodies; bloodbrain barrier; clinical translation; receptor-mediated transcytosis; safety and toxicology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Macromolecular Substances Limits: Humans Language: En Journal: Ther Deliv Year: 2015 Type: Article Affiliation country: United kingdom

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