Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation.

Grosse, Laura; Hoogenboezem, Thomas; Ambrée, Oliver; Bellingrath, Silja; Jörgens, Silke; de Wit, Harm J; Wijkhuijs, Annemarie M; Arolt, Volker; Drexhage, Hemmo A

Grosse, Laura; Hoogenboezem, Thomas; Ambrée, Oliver; Bellingrath, Silja; Jörgens, Silke; de Wit, Harm J; Wijkhuijs, Annemarie M; Arolt, Volker; Drexhage, Hemmo A.

Affiliation

Grosse L; Department of Psychiatry, University of Muenster, Germany; Radiology Morphological Solutions, Rotterdam, The Netherlands. Electronic address: laura.grosse@ukmuenster.de.
Hoogenboezem T; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
Ambrée O; Department of Psychiatry, University of Muenster, Germany.
Bellingrath S; Department of Psychology, University of Duisburg-Essen, Germany.
Jörgens S; Department of Psychiatry, University of Muenster, Germany.
de Wit HJ; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
Wijkhuijs AM; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
Arolt V; Department of Psychiatry, University of Muenster, Germany.
Drexhage HA; Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.

Brain Behav Immun ; 54: 38-44, 2016 May.

Article in En | MEDLINE | ID: mdl-26674997

Subject(s)

Depressive Disorder, Major/immunology; Killer Cells, Natural/immunology; Monocytes/immunology; T-Lymphocytes, Regulatory/immunology; Th17 Cells/immunology; Th2 Cells/immunology; Adult; Case-Control Studies; Cytokines/metabolism; Depressive Disorder, Major/metabolism; Depressive Disorder, Major/pathology; Female; Humans; Killer Cells, Natural/pathology; Lymphocyte Activation; Male; Middle Aged; Monocytes/pathology; T-Lymphocytes, Regulatory/pathology; Th17 Cells/pathology; Th2 Cells/pathology

Key words

Inflammation; Lymphocytes; Major depressive disorder; Monocyte gene expression; Natural killer cells; T helper cells; T regulatory cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Monocytes / T-Lymphocytes, Regulatory / Th2 Cells / Depressive Disorder, Major / Th17 Cells Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Brain Behav Immun Journal subject: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Year: 2016 Type: Article

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