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Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Burak, M Furkan; Inouye, Karen E; White, Ariel; Lee, Alexandra; Tuncman, Gurol; Calay, Ediz S; Sekiya, Motohiro; Tirosh, Amir; Eguchi, Kosei; Birrane, Gabriel; Lightwood, Daniel; Howells, Louise; Odede, Geofrey; Hailu, Hanna; West, Shauna; Garlish, Rachel; Neale, Helen; Doyle, Carl; Moore, Adrian; Hotamisligil, Gökhan S.
Affiliation
  • Burak MF; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Inouye KE; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • White A; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Lee A; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Tuncman G; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Calay ES; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Sekiya M; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Tirosh A; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Eguchi K; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Birrane G; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  • Lightwood D; UCB (Union Chimique Belge), 208 Bath Road, Slough, Berkshire SL1 3WE, UK.
  • Howells L; UCB (Union Chimique Belge), 208 Bath Road, Slough, Berkshire SL1 3WE, UK.
  • Odede G; UCB (Union Chimique Belge), 208 Bath Road, Slough, Berkshire SL1 3WE, UK.
  • Hailu H; UCB (Union Chimique Belge), 208 Bath Road, Slough, Berkshire SL1 3WE, UK.
  • West S; UCB (Union Chimique Belge), 208 Bath Road, Slough, Berkshire SL1 3WE, UK.
  • Garlish R; UCB (Union Chimique Belge), 208 Bath Road, Slough, Berkshire SL1 3WE, UK.
  • Neale H; UCB (Union Chimique Belge), 208 Bath Road, Slough, Berkshire SL1 3WE, UK.
  • Doyle C; UCB (Union Chimique Belge), 208 Bath Road, Slough, Berkshire SL1 3WE, UK.
  • Moore A; UCB (Union Chimique Belge), 208 Bath Road, Slough, Berkshire SL1 3WE, UK.
  • Hotamisligil GS; Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. ghotamis@hsph.harvard.edu.
Sci Transl Med ; 7(319): 319ra205, 2015 Dec 23.
Article in En | MEDLINE | ID: mdl-26702093
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Fatty Acid-Binding Proteins / Antibodies, Monoclonal Limits: Animals / Humans / Male Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2015 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Fatty Acid-Binding Proteins / Antibodies, Monoclonal Limits: Animals / Humans / Male Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2015 Type: Article Affiliation country: United States