Biomimetic Approaches Towards The Synthesis of Complex Dimeric Natural Products.

Stanley, Paul A; Spiteri, Christian; Moore, Jonathan C; Barrow, Andrew S; Sharma, Pallavi; Moses, John E

Stanley, Paul A; Spiteri, Christian; Moore, Jonathan C; Barrow, Andrew S; Sharma, Pallavi; Moses, John E.

Affiliation

Moses JE; School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK. John.moses@nottingham.ac.uk.

Curr Pharm Des ; 22(12): 1628-57, 2016.

Article in En | MEDLINE | ID: mdl-26721256

ABSTRACT

ABSTRACT

We present a selection of elegant and diverse biomimetic syntheses of complex natural product dimers. The dimerisation pathways discussed encompass the most prevalent strategies, including Diels-Alder, Aldol, Mannich, conjugate addition, oxidative, radical and photochemical approaches; each underpinned through rational biosynthetic speculation.

Subject(s)

Biological Products/chemical synthesis; Biomimetics/methods; Chemistry Techniques, Synthetic/methods; Biological Products/chemistry; Dimerization; Humans; Molecular Structure

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Collection: 01-internacional Database: MEDLINE Main subject: Biological Products / Biomimetics / Chemistry Techniques, Synthetic Limits: Humans Language: En Journal: Curr Pharm Des Journal subject: FARMACIA Year: 2016 Type: Article

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