Progestin treatment decreases CD133+ cancer stem cell populations in endometrial cancer.

Guy, Michael S; Qamar, Lubna; Behbakht, Kian; Post, Miriam D; Sheeder, Jeanelle; Sartorius, Carol A; Spillman, Monique A

Guy, Michael S; Qamar, Lubna; Behbakht, Kian; Post, Miriam D; Sheeder, Jeanelle; Sartorius, Carol A; Spillman, Monique A.

Affiliation

Guy MS; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Cincinnati School of Medicine, Cincinnati, OH 45219, USA. Electronic address: michael.s.guy@gmail.com.
Qamar L; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Behbakht K; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Post MD; Department of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Sheeder J; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Sartorius CA; Department of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA.
Spillman MA; Texas Oncology, Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA.

Gynecol Oncol ; 140(3): 518-26, 2016 Mar.

Article in En | MEDLINE | ID: mdl-26731726

Subject(s)

Adenocarcinoma/drug therapy; Adenocarcinoma/metabolism; Antigens, CD; Antineoplastic Agents, Hormonal/pharmacology; Endometrial Neoplasms/drug therapy; Endometrial Neoplasms/metabolism; Glycoproteins; Medroxyprogesterone Acetate/pharmacology; Neoplastic Stem Cells/drug effects; Peptides; AC133 Antigen; Adult; Aged; Antigens, CD/metabolism; Antineoplastic Agents, Hormonal/therapeutic use; Apoptosis/drug effects; Cell Count; Cell Line, Tumor; Female; Glycoproteins/metabolism; Humans; Medroxyprogesterone Acetate/therapeutic use; Middle Aged; Neoplastic Stem Cells/metabolism; Peptides/metabolism; Receptors, Androgen/metabolism; Receptors, Estrogen/metabolism; Receptors, Progesterone/metabolism

Key words

Cancer stem cells; Endometrial cancer; Hormonal treatment; Progesterone; Progestin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Neoplastic Stem Cells / Glycoproteins / Adenocarcinoma / Antigens, CD / Endometrial Neoplasms / Medroxyprogesterone Acetate / Antineoplastic Agents, Hormonal Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: Gynecol Oncol Year: 2016 Type: Article

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