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The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat.
Kuntz, Kevin W; Campbell, John E; Keilhack, Heike; Pollock, Roy M; Knutson, Sarah K; Porter-Scott, Margaret; Richon, Victoria M; Sneeringer, Chris J; Wigle, Tim J; Allain, Christina J; Majer, Christina R; Moyer, Mikel P; Copeland, Robert A; Chesworth, Richard.
Affiliation
  • Kuntz KW; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Campbell JE; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Keilhack H; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Pollock RM; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Knutson SK; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Porter-Scott M; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Richon VM; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Sneeringer CJ; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Wigle TJ; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Allain CJ; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Majer CR; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Moyer MP; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Copeland RA; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
  • Chesworth R; Epizyme , 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States.
J Med Chem ; 59(4): 1556-64, 2016 Feb 25.
Article in En | MEDLINE | ID: mdl-26769278

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Enzyme Inhibitors / Small Molecule Libraries / Polycomb Repressive Complex 2 / Methylation Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Enzyme Inhibitors / Small Molecule Libraries / Polycomb Repressive Complex 2 / Methylation Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Type: Article Affiliation country: United States