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Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Mullarky, Edouard; Lucki, Natasha C; Beheshti Zavareh, Reza; Anglin, Justin L; Gomes, Ana P; Nicolay, Brandon N; Wong, Jenny C Y; Christen, Stefan; Takahashi, Hidenori; Singh, Pradeep K; Blenis, John; Warren, J David; Fendt, Sarah-Maria; Asara, John M; DeNicola, Gina M; Lyssiotis, Costas A; Lairson, Luke L; Cantley, Lewis C.
Affiliation
  • Mullarky E; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065; Biological and Biomedical Sciences Graduate Program, Harvard Medical School, Boston, MA 02115;
  • Lucki NC; The California Institute for Biomedical Research, La Jolla, CA 92037;
  • Beheshti Zavareh R; The California Institute for Biomedical Research, La Jolla, CA 92037;
  • Anglin JL; The California Institute for Biomedical Research, La Jolla, CA 92037;
  • Gomes AP; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065;
  • Nicolay BN; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129;
  • Wong JC; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;
  • Christen S; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Vesalius Research Center, Vlaams Instituut voor Biotechnologie Leuven, 3000 Leuven, Belgium;
  • Takahashi H; Department of Systems Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115; Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115;
  • Singh PK; Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065; Milstein Chemistry Core Facility, Weill Cornell Medical College, New York, NY 10065;
  • Blenis J; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065;
  • Warren JD; Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065; Milstein Chemistry Core Facility, Weill Cornell Medical College, New York, NY 10065;
  • Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Vesalius Research Center, Vlaams Instituut voor Biotechnologie Leuven, 3000 Leuven, Belgium;
  • Asara JM; Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115;
  • DeNicola GM; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;
  • Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109; lcantley@med.cornell.edu clyssiot@med.umich.edu llairson@scripps.edu.
  • Lairson LL; The California Institute for Biomedical Research, La Jolla, CA 92037; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 lcantley@med.cornell.edu clyssiot@med.umich.edu llairson@scripps.edu.
  • Cantley LC; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065; lcantley@med.cornell.edu clyssiot@med.umich.edu llairson@scripps.edu.
Proc Natl Acad Sci U S A ; 113(7): 1778-83, 2016 Feb 16.
Article in En | MEDLINE | ID: mdl-26831078
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Phosphoglycerate Dehydrogenase / Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Phosphoglycerate Dehydrogenase / Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Type: Article