Human innate lymphoid cells.
Immunol Lett
; 179: 2-8, 2016 11.
Article
in En
| MEDLINE
| ID: mdl-26844414
ABSTRACT
The interest in innate lymphoid cells (ILC) has rapidly grown during the last decade. ILC include distinct cell types that are collectively involved in host protection against pathogens and tumor cells and in the regulation of tissue homeostasis. Studies in mice enabled a broad characterization of ILC function and of their developmental requirements. In humans all mature ILC subsets have been characterized and their role in the pathogenesis of certain disease is emerging. Nonetheless, still limited information is available on human ILC development. Indeed, only the cell precursors committed toward NK cells or ILC3 have been described. Here, we review the most recent finding on human mature ILC, discussing their tissue localization and function. Moreover, we summarize the available data regarding human ILC development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocyte Subsets
/
Immunity, Innate
Limits:
Animals
/
Humans
Language:
En
Journal:
Immunol Lett
Year:
2016
Type:
Article
Affiliation country:
Italy