Your browser doesn't support javascript.
loading
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Mavrakis, Konstantinos J; McDonald, E Robert; Schlabach, Michael R; Billy, Eric; Hoffman, Gregory R; deWeck, Antoine; Ruddy, David A; Venkatesan, Kavitha; Yu, Jianjun; McAllister, Gregg; Stump, Mark; deBeaumont, Rosalie; Ho, Samuel; Yue, Yingzi; Liu, Yue; Yan-Neale, Yan; Yang, Guizhi; Lin, Fallon; Yin, Hong; Gao, Hui; Kipp, D Randal; Zhao, Songping; McNamara, Joshua T; Sprague, Elizabeth R; Zheng, Bing; Lin, Ying; Cho, Young Shin; Gu, Justin; Crawford, Kenneth; Ciccone, David; Vitari, Alberto C; Lai, Albert; Capka, Vladimir; Hurov, Kristen; Porter, Jeffery A; Tallarico, John; Mickanin, Craig; Lees, Emma; Pagliarini, Raymond; Keen, Nicholas; Schmelzle, Tobias; Hofmann, Francesco; Stegmeier, Frank; Sellers, William R.
Affiliation
  • Mavrakis KJ; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • McDonald ER; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Schlabach MR; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Billy E; Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.
  • Hoffman GR; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • deWeck A; Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.
  • Ruddy DA; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Venkatesan K; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Yu J; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • McAllister G; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Stump M; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • deBeaumont R; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Ho S; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Yue Y; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Liu Y; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Yan-Neale Y; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Yang G; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Lin F; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Yin H; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Gao H; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Kipp DR; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Zhao S; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • McNamara JT; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Sprague ER; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Zheng B; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • Lin Y; China Novartis Institutes for Biomedical Research, Shanghai 201203, China.
  • Cho YS; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Gu J; China Novartis Institutes for Biomedical Research, Shanghai 201203, China.
  • Crawford K; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • Ciccone D; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Vitari AC; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • Lai A; Novartis Institutes for Biomedical Research, Emeryville, CA 94608, USA.
  • Capka V; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Hurov K; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Porter JA; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Tallarico J; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Mickanin C; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Lees E; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Pagliarini R; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Keen N; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.
  • Schmelzle T; Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.
  • Hofmann F; Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.
  • Stegmeier F; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA. william.sellers@novartis.com fstegmeier@ksqtx.com.
  • Sellers WR; Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA. william.sellers@novartis.com fstegmeier@ksqtx.com.
Science ; 351(6278): 1208-13, 2016 Mar 11.
Article in En | MEDLINE | ID: mdl-26912361
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Arginine N-Methyltransferases / Purine-Nucleoside Phosphorylase / Cyclin-Dependent Kinase Inhibitor p16 / Methionine / Neoplasms Limits: Humans Language: En Journal: Science Year: 2016 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Arginine N-Methyltransferases / Purine-Nucleoside Phosphorylase / Cyclin-Dependent Kinase Inhibitor p16 / Methionine / Neoplasms Limits: Humans Language: En Journal: Science Year: 2016 Type: Article Affiliation country: United States