Nonsteroidal anti-inflammatory-induced inhibition of signal transducer and activator of transcription 6 (STAT-6) phosphorylation in aspirin-exacerbated respiratory disease.

Katial, Rohit K; Martucci, Michael; Burnett, Trever; Faino, Anna; Finkas, Lindsay; Liu, Sucai; Alam, Rafeul

Katial, Rohit K; Martucci, Michael; Burnett, Trever; Faino, Anna; Finkas, Lindsay; Liu, Sucai; Alam, Rafeul.

Affiliation

Katial RK; National Jewish Health, Denver, Colo. Electronic address: katialr@njhealth.org.
Martucci M; National Jewish Health, Denver, Colo.
Burnett T; National Jewish Health, Denver, Colo.
Faino A; National Jewish Health, Denver, Colo.
Finkas L; National Jewish Health, Denver, Colo.
Liu S; National Jewish Health, Denver, Colo.
Alam R; National Jewish Health, Denver, Colo.

J Allergy Clin Immunol ; 138(2): 579-85, 2016 08.

Article in En | MEDLINE | ID: mdl-26915678

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Aspirin/adverse effects; Drug Hypersensitivity/immunology; Drug Hypersensitivity/metabolism; Respiratory Tract Diseases/metabolism; STAT6 Transcription Factor/metabolism; Signal Transduction/drug effects; Asthma/etiology; Asthma/metabolism; Case-Control Studies; Cytokines/biosynthesis; Humans; Phosphorylation; Respiratory Tract Diseases/etiology; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; T-Lymphocytes/metabolism

Key words

Aspirin-exacerbated respiratory disease; IL-4 signaling inhibition; mechanism of aspirin desensitization; pSTAT6 inhibition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Tract Diseases / Signal Transduction / Anti-Inflammatory Agents, Non-Steroidal / Aspirin / Drug Hypersensitivity / STAT6 Transcription Factor Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Allergy Clin Immunol Year: 2016 Type: Article

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