LC-ESI-MS/MS estimation of loratadine-loaded self-nanoemulsifying drug delivery systems in rat plasma: Pharmacokinetic evaluation and computer simulations by GastroPlus&#8482;.

Verma, Samridhi; Singh, Sandeep Kumar

LC-ESI-MS/MS estimation of loratadine-loaded self-nanoemulsifying drug delivery systems in rat plasma: Pharmacokinetic evaluation and computer simulations by GastroPlus™.

Verma, Samridhi; Singh, Sandeep Kumar.

Affiliation

Verma S; Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
Singh SK; Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India. Electronic address: dr.sandeep_pharmaceutics@yahoo.com.

J Pharm Biomed Anal ; 124: 10-21, 2016 May 30.

Article in En | MEDLINE | ID: mdl-26922577

Subject(s)

Chromatography, Liquid/methods; Computer Simulation; Drug Delivery Systems; Histamine H1 Antagonists, Non-Sedating/pharmacokinetics; Loratadine/pharmacokinetics; Spectrometry, Mass, Electrospray Ionization/methods; Tandem Mass Spectrometry/methods; Animals; Emulsions; Histamine H1 Antagonists, Non-Sedating/administration & dosage; Histamine H1 Antagonists, Non-Sedating/blood; Loratadine/administration & dosage; Loratadine/blood; Rats; Sensitivity and Specificity

Key words

GastroPlus™ simulation; In vitroin vivo correlation; LCMS/MS validation; Loratadine-SNEDDS; Pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Computer Simulation / Chromatography, Liquid / Drug Delivery Systems / Loratadine / Spectrometry, Mass, Electrospray Ionization / Histamine H1 Antagonists, Non-Sedating / Tandem Mass Spectrometry Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: J Pharm Biomed Anal Year: 2016 Type: Article Affiliation country: India

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