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A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission.
Yu, Nam-Kyung; Kim, Hyoung F; Shim, Jaehoon; Kim, Somi; Kim, Dae Won; Kwak, Chuljung; Sim, Su-Eon; Choi, Jun-Hyeok; Ahn, Seohee; Yoo, Juyoun; Choi, Sun-Lim; Jang, Deok-Jin; Lim, Chae-Seok; Lee, Yong-Seok; Kang, Chulhun; Choi, Soo Young; Kaang, Bong-Kiun.
Affiliation
  • Yu NK; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Kim HF; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Shim J; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, South Korea.
  • Kim S; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Kim DW; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Kwak C; Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon, South Korea.
  • Sim SE; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Choi JH; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Ahn S; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Yoo J; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Choi SL; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Jang DJ; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Lim CS; Applied Biology, College of Ecological Environment, Kyungpook National University, 386, Gajang-dong, Sang-Ju, South Korea.
  • Lee YS; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
  • Kang C; Department of Life Science, Chung-Ang University, Seoul, South Korea.
  • Choi SY; Graduate School of East-West Medical Science, Kyung Hee University, Kyungkee-do, South Korea.
  • Kaang BK; Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon, South Korea.
Sci Rep ; 6: 22892, 2016 Mar 10.
Article in En | MEDLINE | ID: mdl-26961175
Cell-permeable proteins are emerging as unconventional regulators of signal transduction and providing a potential for therapeutic applications. However, only a few of them are identified and studied in detail. We identify a novel cell-permeable protein, mouse LLP homolog (mLLP), and uncover its roles in regulating neural development. We found that mLLP is strongly expressed in developing nervous system and that mLLP knockdown or overexpression during maturation of cultured neurons affected the neuronal growth and synaptic transmission. Interestingly, extracellular addition of mLLP protein enhanced dendritic arborization, demonstrating the non-cell-autonomous effect of mLLP. Moreover, mLLP interacts with CCCTC-binding factor (CTCF) as well as transcriptional machineries and modulates gene expression involved in neuronal growth. Together, these results illustrate the characteristics and roles of previously unknown cell-permeable protein mLLP in modulating neural development.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2016 Type: Article Affiliation country: Korea (South)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2016 Type: Article Affiliation country: Korea (South)