In vivo risk evaluation of carbon-coated iron carbide nanoparticles based on short- and long-term exposure scenarios.
Nanomedicine (Lond)
; 11(7): 783-96, 2016 Apr.
Article
in En
| MEDLINE
| ID: mdl-26979124
ABSTRACT
BACKGROUND:
While carbon-encapsulated iron carbide nanoparticles exhibit strong magnetic properties appealing for biomedical applications, potential side effects of such materials remain comparatively poorly understood. Here, we assess the effects of iron-based nanoparticles in an in vivo long-term study in mice with observation windows between 1 week and 1 year. MATERIALS &METHODS:
Functionalized (PEG or IgG) carbon-encapsulated platinum-spiked iron carbide nanoparticles were injected intravenously in mice (single or repeated dose administration).RESULTS:
One week after administration, magnetic nanoparticles were predominantly localized in organs of the reticuloendothelial system, particularly the lung and liver. After 1 year, particles were still present in these organs, however, without any evident tissue alterations, such as inflammation, fibrosis, necrosis or carcinogenesis. Importantly, reticuloendothelial system organs presented with normal function.CONCLUSION:
This long-term exposure study shows high in vivo compatibility of intravenously applied carbon-encapsulated iron nanoparticles suggesting continuing investigations on such materials for biomedical applications.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carbon
/
Drug Carriers
/
Iron Compounds
/
Carbon Compounds, Inorganic
/
Coated Materials, Biocompatible
/
Nanoparticles
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Nanomedicine (Lond)
Year:
2016
Type:
Article
Affiliation country:
Switzerland