Statin modulation of monocyte phenotype and function: implications for HIV-1-associated neurocognitive disorders.

Yadav, Anjana; Betts, Michael R; Collman, Ronald G

Yadav, Anjana; Betts, Michael R; Collman, Ronald G.

Affiliation

Yadav A; Department of Medicine, University of Pennsylvania Perelman School of Medicine, 36th and Hamilton Walk, Philadelphia, PA, 19104, USA.
Betts MR; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, 36th and Hamilton Walk, Philadelphia, PA, 19104, USA.
Collman RG; Department of Medicine, University of Pennsylvania Perelman School of Medicine, 36th and Hamilton Walk, Philadelphia, PA, 19104, USA. collmanr@mail.med.upenn.edu.

J Neurovirol ; 22(5): 584-596, 2016 10.

Article in En | MEDLINE | ID: mdl-27021071

Subject(s)

Atorvastatin/pharmacology; Gene Expression Regulation/drug effects; Monocytes/drug effects; Simvastatin/pharmacology; AIDS Dementia Complex/genetics; AIDS Dementia Complex/immunology; AIDS Dementia Complex/pathology; Antigens, CD/genetics; Antigens, CD/immunology; Antigens, Differentiation, Myelomonocytic/genetics; Antigens, Differentiation, Myelomonocytic/immunology; Chemokine CCL2/genetics; Chemokine CCL2/immunology; Chemokine CCL2/pharmacology; Chemokine CCL3/genetics; Chemokine CCL3/immunology; Chemotaxis; GPI-Linked Proteins/genetics; GPI-Linked Proteins/immunology; Gene Expression Regulation/immunology; Healthy Volunteers; Humans; Interleukin-8/genetics; Interleukin-8/immunology; Lipopolysaccharide Receptors/genetics; Lipopolysaccharide Receptors/immunology; Lipopolysaccharides/antagonists & inhibitors; Lipopolysaccharides/pharmacology; Models, Biological; Monocytes/cytology; Monocytes/immunology; Phenotype; Primary Cell Culture; Receptors, Cell Surface/genetics; Receptors, Cell Surface/immunology; Receptors, IgG/genetics; Receptors, IgG/immunology; Signal Transduction

Key words

HAND; Monocyte; NeuroAIDS; Statin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocytes / Gene Expression Regulation / Simvastatin / Atorvastatin Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: J Neurovirol Journal subject: NEUROLOGIA / VIROLOGIA Year: 2016 Type: Article Affiliation country: United States

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