The influence of locally applied granulocyte-colony stimulating factor on osteoporotic bone.
Clin Oral Implants Res
; 28(5): 586-593, 2017 May.
Article
in En
| MEDLINE
| ID: mdl-27038192
ABSTRACT
OBJECTIVES:
The compromised capacity of bone healing in osteoporotic population renders a serious concern of patients and clinicians. This study aimed to investigate the influence of G-CSF on bone reconstruction using an osteoporotic animal model. MATERIALS ANDMETHODS:
Sixty skeletal mature female Spraque-Dawley rats underwent bilateral ovariectomy (OVX) and were assigned into three groups (n = 20). Three months after OVX, defects of 5 mm in cranial and 2 mm in femur were surgically created on all the animals. The defects were left unfilled, filled with gelatin sponge (GS), or filled with granulocyte-colony stimulating factor (G-CSF) infused GS. Specimens were retrieved for histomorphometric and micro-CT analyses at weeks 1, 4, 8, and 12 after surgery.RESULTS:
At early stage of week 1 to week 8, the histomorphometric and micro-CT analysis demonstrated more advanced bone formation in femur in the control group; by week 12, all groups achieved cortical closure. In cranial bone, more advanced bone formation was exhibited in G-CSF-treated group at both early and late stages, although this observation was not statistically significant.CONCLUSIONS:
The results indicated that in osteoporotic bone, G-CSF may advance bone healing in cranial bone where spontaneous bone formation was insufficient.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoporosis
/
Granulocyte Colony-Stimulating Factor
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Clin Oral Implants Res
Journal subject:
ODONTOLOGIA
Year:
2017
Type:
Article
Affiliation country:
China