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Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.
Heslop, James A; Rowe, Cliff; Walsh, Joanne; Sison-Young, Rowena; Jenkins, Roz; Kamalian, Laleh; Kia, Richard; Hay, David; Jones, Robert P; Malik, Hassan Z; Fenwick, Stephen; Chadwick, Amy E; Mills, John; Kitteringham, Neil R; Goldring, Chris E P; Kevin Park, B.
Affiliation
  • Heslop JA; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
  • Rowe C; CN Bio, Centre for Innovation and Enterprise, Oxford University Begbroke Science Park, Begbroke, Oxfordshire, OX5 1PF, UK.
  • Walsh J; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
  • Sison-Young R; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
  • Jenkins R; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
  • Kamalian L; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
  • Kia R; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
  • Hay D; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
  • Jones RP; University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK.
  • Malik HZ; University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK.
  • Fenwick S; University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK.
  • Chadwick AE; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
  • Mills J; AstraZeneca, Personalised Healthcare and Biomarkers, Alderley Park, Cheshire, SK10 4TG, UK.
  • Kitteringham NR; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
  • Goldring CE; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK. Chrissy@liv.ac.uk.
  • Kevin Park B; Division of Molecular and Clinical Pharmacology, The Institute of Translational Medicine, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool, L69 3GE, UK.
Arch Toxicol ; 91(1): 439-452, 2017 Jan.
Article in En | MEDLINE | ID: mdl-27039104
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacology / Toxicology / Gene Expression Regulation, Developmental / Proteome / Hepatocytes Type of study: Evaluation_studies / Prognostic_studies Limits: Humans Language: En Journal: Arch Toxicol Year: 2017 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacology / Toxicology / Gene Expression Regulation, Developmental / Proteome / Hepatocytes Type of study: Evaluation_studies / Prognostic_studies Limits: Humans Language: En Journal: Arch Toxicol Year: 2017 Type: Article Affiliation country: United kingdom