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sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance.
Kaur, Amanpreet; Webster, Marie R; Marchbank, Katie; Behera, Reeti; Ndoye, Abibatou; Kugel, Curtis H; Dang, Vanessa M; Appleton, Jessica; O'Connell, Michael P; Cheng, Phil; Valiga, Alexander A; Morissette, Rachel; McDonnell, Nazli B; Ferrucci, Luigi; Kossenkov, Andrew V; Meeth, Katrina; Tang, Hsin-Yao; Yin, Xiangfan; Wood, William H; Lehrmann, Elin; Becker, Kevin G; Flaherty, Keith T; Frederick, Dennie T; Wargo, Jennifer A; Cooper, Zachary A; Tetzlaff, Michael T; Hudgens, Courtney; Aird, Katherine M; Zhang, Rugang; Xu, Xiaowei; Liu, Qin; Bartlett, Edmund; Karakousis, Giorgos; Eroglu, Zeynep; Lo, Roger S; Chan, Matthew; Menzies, Alexander M; Long, Georgina V; Johnson, Douglas B; Sosman, Jeffrey; Schilling, Bastian; Schadendorf, Dirk; Speicher, David W; Bosenberg, Marcus; Ribas, Antoni; Weeraratna, Ashani T.
Affiliation
  • Kaur A; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Webster MR; University of the Sciences, Philadelphia, Pennsylvania 19104, USA.
  • Marchbank K; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Behera R; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Ndoye A; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Kugel CH; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Dang VM; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Appleton J; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • O'Connell MP; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Cheng P; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Valiga AA; Department of Dermatology, University of Zurich, Zurich CH-8006, Switzerland.
  • Morissette R; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • McDonnell NB; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
  • Ferrucci L; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
  • Kossenkov AV; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
  • Meeth K; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Tang HY; Department of Dermatology and Pathology, Yale University, New Haven, Connecticut 06511, USA.
  • Yin X; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Wood WH; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Lehrmann E; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
  • Becker KG; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
  • Flaherty KT; The National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
  • Frederick DT; Massachusetts General Hospital Cancer Center, Developmental Therapeutics, Boston 02114, Massachusetts, USA.
  • Wargo JA; Massachusetts General Hospital Cancer Center, Developmental Therapeutics, Boston 02114, Massachusetts, USA.
  • Cooper ZA; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Tetzlaff MT; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Hudgens C; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Aird KM; Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
  • Zhang R; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Xu X; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Liu Q; Departments of Surgery and Pathology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
  • Bartlett E; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
  • Karakousis G; Departments of Surgery and Pathology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
  • Eroglu Z; Departments of Surgery and Pathology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
  • Lo RS; Department of Medical Oncology, City of Hope Medical Center, Duarte, California 91010, USA.
  • Chan M; Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles, Los Angeles, California 90095, USA.
  • Menzies AM; Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead 2145, Australia.
  • Long GV; Melanoma Institute Australia and The University of Sydney, Sydney 2000, Australia.
  • Johnson DB; Melanoma Institute Australia and The University of Sydney, Sydney 2000, Australia.
  • Sosman J; Department of Medicine, Vanderbilt University Medical Center, Nashville Tennessee 37232, USA.
  • Schilling B; Department of Medicine, Vanderbilt University Medical Center, Nashville Tennessee 37232, USA.
  • Schadendorf D; Department of Dermatology, University Hospital, West German Cancer Center, University Duesburg-Essen, Essen, Germany.
  • Speicher DW; German Cancer Consortium (DKTK), Heidelberg 45127, Germany.
  • Bosenberg M; Department of Dermatology, University Hospital, West German Cancer Center, University Duesburg-Essen, Essen, Germany.
  • Ribas A; German Cancer Consortium (DKTK), Heidelberg 45127, Germany.
  • Weeraratna AT; The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Nature ; 532(7598): 250-4, 2016 Apr 14.
Article in En | MEDLINE | ID: mdl-27042933

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Drug Resistance, Neoplasm / Tumor Microenvironment / Melanoma / Membrane Proteins / Neoplasm Metastasis Type of study: Prognostic_studies Limits: Adult / Animals / Humans / Male / Middle aged Language: En Journal: Nature Year: 2016 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Drug Resistance, Neoplasm / Tumor Microenvironment / Melanoma / Membrane Proteins / Neoplasm Metastasis Type of study: Prognostic_studies Limits: Adult / Animals / Humans / Male / Middle aged Language: En Journal: Nature Year: 2016 Type: Article Affiliation country: United States