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Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Miles, Timothy J; Hennessy, Alan J; Bax, Ben; Brooks, Gerald; Brown, Barry S; Brown, Pamela; Cailleau, Nathalie; Chen, Dongzhao; Dabbs, Steven; Davies, David T; Esken, Joel M; Giordano, Ilaria; Hoover, Jennifer L; Jones, Graham E; Kusalakumari Sukmar, Senthill K; Markwell, Roger E; Minthorn, Elisabeth A; Rittenhouse, Steve; Gwynn, Michael N; Pearson, Neil D.
Affiliation
  • Miles TJ; Diseases of the Developing World CEDD, GlaxoSmithKline, Calle Severo Ochoa, 2, 28760 Tres Cantos, Madrid, Spain. Electronic address: tim.j.miles@gsk.com.
  • Hennessy AJ; Infectious Diseases CEDD, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Bax B; Platform Technology & Science, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Brooks G; Infectious Diseases CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK.
  • Brown BS; Infectious Diseases CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Brown P; Infectious Diseases CEDD, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Cailleau N; Infectious Diseases CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK.
  • Chen D; Infectious Diseases CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Dabbs S; Infectious Diseases CEDD, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
  • Davies DT; Infectious Diseases CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK.
  • Esken JM; Infectious Diseases CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Giordano I; Diseases of the Developing World CEDD, GlaxoSmithKline, Calle Severo Ochoa, 2, 28760 Tres Cantos, Madrid, Spain.
  • Hoover JL; Infectious Diseases CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Jones GE; Infectious Diseases CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK.
  • Kusalakumari Sukmar SK; Infectious Diseases CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Markwell RE; Infectious Diseases CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK.
  • Minthorn EA; Oncology TA, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Rittenhouse S; Infectious Diseases CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Gwynn MN; Infectious Diseases CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  • Pearson ND; Infectious Diseases CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
Bioorg Med Chem Lett ; 26(10): 2464-2469, 2016 05 15.
Article in En | MEDLINE | ID: mdl-27055939
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Topoisomerase II Inhibitors / Heterocyclic Compounds, 4 or More Rings / Heterocyclic Compounds, 3-Ring / Anti-Bacterial Agents Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Topoisomerase II Inhibitors / Heterocyclic Compounds, 4 or More Rings / Heterocyclic Compounds, 3-Ring / Anti-Bacterial Agents Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article