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Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans.
Hohmann, Nicolas; Reinhard, Raphael; Schnaidt, Sven; Witt, Lukas; Carls, Alexandra; Burhenne, Jürgen; Mikus, Gerd; Haefeli, Walter E.
Affiliation
  • Hohmann N; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
  • Reinhard R; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
  • Schnaidt S; Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany.
  • Witt L; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
  • Carls A; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
  • Burhenne J; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
  • Mikus G; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
  • Haefeli WE; Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany walter.emil.haefeli@med.uni-heidelberg.de.
J Antimicrob Chemother ; 71(8): 2241-7, 2016 08.
Article in En | MEDLINE | ID: mdl-27141088
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasma / Midazolam / Anti-HIV Agents / Drug Interactions / Phosphodiesterase 5 Inhibitors / Rilpivirine / Tadalafil Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: J Antimicrob Chemother Year: 2016 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasma / Midazolam / Anti-HIV Agents / Drug Interactions / Phosphodiesterase 5 Inhibitors / Rilpivirine / Tadalafil Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: J Antimicrob Chemother Year: 2016 Type: Article Affiliation country: Germany