Metabolite profiles of rats in repeated dose toxicological studies after oral and inhalative exposure.

Fabian, E; Bordag, N; Herold, M; Kamp, H; Krennrich, G; Looser, R; Ma-Hock, L; Mellert, W; Montoya, G; Peter, E; Prokudin, A; Spitzer, M; Strauss, V; Walk, T; Zbranek, R; van Ravenzwaay, B

Fabian, E; Bordag, N; Herold, M; Kamp, H; Krennrich, G; Looser, R; Ma-Hock, L; Mellert, W; Montoya, G; Peter, E; Prokudin, A; Spitzer, M; Strauss, V; Walk, T; Zbranek, R; van Ravenzwaay, B.

Affiliation

Fabian E; BASF SE Experimental Toxicology and Ecology, Z 470 67056 Ludwigshafen, Germany. Electronic address: eric.fabian@basf.com.
Bordag N; metanomics GmbH, Tegeler Weg 33, 10589 Berlin, Germany. Electronic address: natalie@bordag.com.
Herold M; metanomics GmbH, Tegeler Weg 33, 10589 Berlin, Germany. Electronic address: michael.herold@metanomics.de.
Kamp H; BASF SE Experimental Toxicology and Ecology, Z 470 67056 Ludwigshafen, Germany.
Krennrich G; BASF SE, Scientific Computing, B009 67056 Ludwigshafen, Germany. Electronic address: gerhard.krennrich@basf.com.
Looser R; metanomics GmbH, Tegeler Weg 33, 10589 Berlin, Germany; BASF Schwarzheide GmbH, Schiphauer Strasse 1, 01986 Schwarzheide, Germany. Electronic address: ralf.looser@metanomics.de.
Ma-Hock L; BASF SE Experimental Toxicology and Ecology, Z 470 67056 Ludwigshafen, Germany. Electronic address: lan.ma-hock@basf.com.
Mellert W; BASF SE Experimental Toxicology and Ecology, Z 470 67056 Ludwigshafen, Germany. Electronic address: werner.mellert@basf.com.
Montoya G; BASF SE Experimental Toxicology and Ecology, Z 470 67056 Ludwigshafen, Germany. Electronic address: Gina.MONTOYAPARRA@danone.com.
Peter E; metanomics GmbH, Tegeler Weg 33, 10589 Berlin, Germany. Electronic address: erik.peter@metanomics.de.
Prokudin A; metanomics GmbH, Tegeler Weg 33, 10589 Berlin, Germany. Electronic address: alexander.prokudin@metanomics.de.
Spitzer M; metanomics GmbH, Tegeler Weg 33, 10589 Berlin, Germany. Electronic address: michael.spitzer@metanomics.de.
Strauss V; BASF SE Experimental Toxicology and Ecology, Z 470 67056 Ludwigshafen, Germany. Electronic address: volker.strauss@basf.com.
Walk T; metanomics GmbH, Tegeler Weg 33, 10589 Berlin, Germany. Electronic address: tilmann.walk@metanomics.de.
Zbranek R; BASF SE Experimental Toxicology and Ecology, Z 470 67056 Ludwigshafen, Germany. Electronic address: rene.zbranek@basf.com.
van Ravenzwaay B; BASF SE Experimental Toxicology and Ecology, Z 470 67056 Ludwigshafen, Germany. Electronic address: bennard.ravenzwaay@basf.com.

Toxicol Lett ; 255: 11-23, 2016 Jul 25.

Article in En | MEDLINE | ID: mdl-27153797

Subject(s)

Aniline Compounds/toxicity; Benzene Derivatives/toxicity; Chloroform/toxicity; Dimethylformamide/toxicity; Ethylene Glycols/toxicity; Furans/toxicity; Metabolome; Metabolomics; Toxicity Tests; Administration, Inhalation; Administration, Oral; Aniline Compounds/administration & dosage; Aniline Compounds/pharmacokinetics; Animals; Benzene Derivatives/administration & dosage; Benzene Derivatives/pharmacokinetics; Chloroform/administration & dosage; Chloroform/pharmacokinetics; Databases, Factual; Dimethylformamide/administration & dosage; Dimethylformamide/pharmacokinetics; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylene Glycols/administration & dosage; Ethylene Glycols/pharmacokinetics; Female; Furans/administration & dosage; Furans/pharmacokinetics; Inhalation Exposure; Male; Principal Component Analysis; Rats, Wistar; Risk Assessment

Key words

Oral versus inhalative exposure; Plasma metabolome; Rat

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzene Derivatives / Chloroform / Toxicity Tests / Dimethylformamide / Ethylene Glycols / Metabolome / Metabolomics / Furans / Aniline Compounds Type of study: Etiology_studies / Risk_factors_studies Limits: Animals Language: En Journal: Toxicol Lett Year: 2016 Type: Article

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