Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease.

Békés, Miklós; van der Heden van Noort, Gerbrand J; Ekkebus, Reggy; Ovaa, Huib; Huang, Tony T; Lima, Christopher D

Békés, Miklós; van der Heden van Noort, Gerbrand J; Ekkebus, Reggy; Ovaa, Huib; Huang, Tony T; Lima, Christopher D.

Affiliation

Békés M; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA; Structural Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.
van der Heden van Noort GJ; Division of Cell Biology II, The Netherlands Cancer Institute (NKI), Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Ekkebus R; Division of Cell Biology II, The Netherlands Cancer Institute (NKI), Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Ovaa H; Division of Cell Biology II, The Netherlands Cancer Institute (NKI), Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address: h.ovaa@nki.nl.
Huang TT; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: tony.huang@nyumc.org.
Lima CD; Structural Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA; Howard Hughes Medical Institute, 1275 York Avenue, New York, NY 10065, USA. Electronic address: limac@mskcc.org.

Mol Cell ; 62(4): 572-85, 2016 05 19.

Article in En | MEDLINE | ID: mdl-27203180

Subject(s)

Cysteine Endopeptidases/metabolism; Cytokines/metabolism; Deubiquitinating Enzymes/metabolism; Polyubiquitin/metabolism; Severe acute respiratory syndrome-related coronavirus/enzymology; Ubiquitins/metabolism; Viral Proteins/metabolism; Binding Sites; Coronavirus 3C Proteases; Cysteine Endopeptidases/chemistry; Cysteine Endopeptidases/genetics; Cytokines/chemistry; Deubiquitinating Enzymes/chemistry; HeLa Cells; Humans; Lysine; Models, Molecular; Mutation; Polyubiquitin/chemistry; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Severe acute respiratory syndrome-related coronavirus/genetics; Structure-Activity Relationship; Ubiquitination; Ubiquitins/chemistry; Viral Proteins/chemistry; Viral Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Cysteine Endopeptidases / Ubiquitins / Cytokines / Polyubiquitin / Severe acute respiratory syndrome-related coronavirus / Deubiquitinating Enzymes Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2016 Type: Article Affiliation country: United States

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