Radiation-enhanced therapeutic targeting of galectin-1 enriched malignant stroma in triple negative breast cancer.

Upreti, Meenakshi; Jyoti, Amar; Johnson, Sara E; Swindell, Elden P; Napier, Dana; Sethi, Pallavi; Chan, Ryan; Feddock, Jonathan M; Weiss, Heidi L; O'Halloran, Thomas V; Evers, B Mark

Upreti, Meenakshi; Jyoti, Amar; Johnson, Sara E; Swindell, Elden P; Napier, Dana; Sethi, Pallavi; Chan, Ryan; Feddock, Jonathan M; Weiss, Heidi L; O'Halloran, Thomas V; Evers, B Mark.

Affiliation

Upreti M; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Jyoti A; Department of Pathology, University of Kentucky, Lexington, KY, USA.
Johnson SE; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Swindell EP; Department of Pathology, University of Kentucky, Lexington, KY, USA.
Napier D; Markey Cancer Center, University of Kentucky, Lexington, KY, USA.
Sethi P; Department of Chemistry, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA.
Chan R; Department of Pathology, University of Kentucky, Lexington, KY, USA.
Feddock JM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Weiss HL; Department of Pathology, University of Kentucky, Lexington, KY, USA.
O'Halloran TV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Evers BM; Department of Radiation Medicine, University of Kentucky Chandler Hospital, Lexington, KY, USA.

Oncotarget ; 7(27): 41559-41574, 2016 Jul 05.

Article in En | MEDLINE | ID: mdl-27223428

Subject(s)

Chemoradiotherapy/methods; Galectin 1/antagonists & inhibitors; Galectin 1/metabolism; Molecular Targeted Therapy/methods; Triple Negative Breast Neoplasms/therapy; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Arsenic Trioxide; Arsenicals/administration & dosage; Cell Line, Tumor; Cells, Cultured; Cisplatin/administration & dosage; Female; Human Umbilical Vein Endothelial Cells; Humans; Mesenchymal Stem Cells/drug effects; Mesenchymal Stem Cells/metabolism; Mesenchymal Stem Cells/pathology; Mesenchymal Stem Cells/radiation effects; Mice; Mice, Nude; Middle Aged; Neoplasm Metastasis; Oxides/administration & dosage; Triple Negative Breast Neoplasms/metabolism; Triple Negative Breast Neoplasms/pathology; Xenograft Model Antitumor Assays; Young Adult

Key words

TNBC tumor model; galectin-1; stromal-targeting; triple negative breast cancer; tumor tissue analog (TTA)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Galectin 1 / Molecular Targeted Therapy / Chemoradiotherapy / Triple Negative Breast Neoplasms Type of study: Prognostic_studies Limits: Adult / Animals / Female / Humans / Middle aged Language: En Journal: Oncotarget Year: 2016 Type: Article Affiliation country: United States

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