Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice.
Nat Commun
; 7: 11761, 2016 06 01.
Article
in En
| MEDLINE
| ID: mdl-27249364
ABSTRACT
Earlier diagnosis and treatment of Alzheimer's disease would greatly benefit from the identification of biomarkers at the prodromal stage. Using a prominent animal model of aspects of the disease, we here show using clinically relevant methodologies that very young, pre-pathological PDAPP mice, which overexpress mutant human amyloid precursor protein in the brain, exhibit two cryptic deficits that are normally undetected using standard methods of assessment. Despite learning a spatial memory task normally and displaying normal brain glucose uptake, they display faster forgetting after a long delay following performance to a criterion, together with a strong impairment of brain glucose uptake at the time of attempted memory retrieval. Preliminary observations suggest that these deficits, likely caused by an impairment in systems consolidation, could be rescued by immunotherapy with an anti-ß-amyloid antibody. Our data suggest a biomarker strategy for the early detection of ß-amyloid-related abnormalities.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Amyloid beta-Protein Precursor
/
Antibodies, Neutralizing
/
Alzheimer Disease
/
Glucose
/
Memory Disorders
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Nat Commun
Journal subject:
BIOLOGIA
/
CIENCIA
Year:
2016
Type:
Article
Affiliation country:
United kingdom