Prediction of fetal ductus arteriosus constriction by systemic and local dermatological formulations of NSAIDs based on PK/PD analysis.

Tanaka, Shingo; Hori, Satoko; Satoh, Hiroki; Sawada, Yasufumi

Tanaka, Shingo; Hori, Satoko; Satoh, Hiroki; Sawada, Yasufumi.

Int J Clin Pharmacol Ther ; 54(10): 782-94, 2016 Oct.

Article in En | MEDLINE | ID: mdl-27285464

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/adverse effects; Ductus Arteriosus/drug effects; Fetal Diseases/chemically induced; Models, Biological; Animals; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics; Constriction, Pathologic/chemically induced; Constriction, Pathologic/pathology; Ductus Arteriosus/pathology; Female; Fetal Diseases/pathology; Humans; Pregnancy; Pregnancy Trimester, Third; Rats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Ductus Arteriosus / Fetal Diseases / Models, Biological Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Int J Clin Pharmacol Ther Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2016 Type: Article

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