Plasma lipoproteins and cholesterol metabolism in spontaneously hyperlipemic rats.
Atherosclerosis
; 76(2-3): 163-71, 1989 Apr.
Article
in En
| MEDLINE
| ID: mdl-2730713
ABSTRACT
The aim of this study was to characterize the plasma lipoprotein pattern and some aspects of cholesterol metabolism in a line of hyperlipemic male rats. Plasma cholesterol and triglycerides were increased about 3-fold as compared to control animals (238 vs. 75 and 185 vs. 59 mg/dl respectively). The plasma lipoprotein distribution and the chemical composition of the isolated lipoproteins was unaffected. Plasma triglyceride production rate was increased (40%, P less than 0.01) and post-heparin lipoprotein lipase activity in plasma decreased (-28%, P less than 0.01) in the hyperlipemic rat. The activity of 3 enzymes involved in cholesterol metabolism (HMG-CoA reductase, cholesterol 7 alpha-hydroxylase, and acyl-CoA cholesterol-acyltransferase) did not differ from control values. 3H2O incorporation into digitonin-precipitable sterols, however, was significantly higher than in controls. This finding was due, in part, to an increased liver weight in the hyperlipemic animals. Furthermore kinetic data using 125I-LDL showed that the fractional catabolic rate of lipoprotein was within the normal range, while the synthetic rate of LDL protein was increased (0.67 vs. 0.3 mg/kg/h, P less than 0.01) in the hyperlipemic rat. These observations suggest that multiple metabolic defects underline the hyperlipemia observed in this animal model.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cholesterol
/
Hyperlipidemias
/
Lipoproteins, LDL
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Atherosclerosis
Year:
1989
Type:
Article
Affiliation country:
Italy