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Cerebral Microbleeds in Multiple Sclerosis Evaluated on Susceptibility-weighted Images and Quantitative Susceptibility Maps: A Case-Control Study.
Zivadinov, Robert; Ramasamy, Deepa P; Benedict, Ralph R H; Polak, Paul; Hagemeier, Jesper; Magnano, Christopher; Dwyer, Michael G; Bergsland, Niels; Bertolino, Nicola; Weinstock-Guttman, Bianca; Kolb, Channa; Hojnacki, David; Utriainen, David; Haacke, E Mark; Schweser, Ferdinand.
Affiliation
  • Zivadinov R; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Ramasamy DP; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Benedict RR; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Polak P; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Hagemeier J; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Magnano C; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Dwyer MG; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Bergsland N; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Bertolino N; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Weinstock-Guttman B; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Kolb C; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Hojnacki D; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Utriainen D; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Haacke EM; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
  • Schweser F; From the Buffalo Neuroimaging Analysis Ctr, Dept of Neurology (R.Z., D.P.R., P.P., J.H., C.M., M.G.D., N. Bergsland, N. Bertolino, F.S.), MR Imaging Clinical and Translational Research Ctr (R.Z., C.M., F.S.), and Jacobs Multiple Sclerosis Ctr, Dept of Neurology (R.R.H.B., B.W.G., C.K., D.H.), Jacobs
Radiology ; 281(3): 884-895, 2016 Dec.
Article in En | MEDLINE | ID: mdl-27308776
Purpose To assess cerebral microbleed (CMB) prevalence in patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) and associations with clinical outcomes. Materials and Methods CMBs are associated with aging and neurodegenerative disorders. The prevalence of CMBs has not previously been well established. In this study, 445 patients with MS (266 with relapsing-remitting MS, 138 with secondary progressive MS, and 41 with primary progressive MS), 45 patients with CIS, 51 patients with other neurological diseases, and 177 healthy control subjects (HCs) underwent 3-T magnetic resonance (MR) imaging and clinical examinations. A subset of 168 patients with MS and 50 HCs underwent neuropsychological testing. Number of CMBs was assessed on susceptibility-weighted minimum intensity projections by using the Microbleed Anatomic Rating Scale; volume was calculated by using quantitative susceptibility maps. Differences between groups were analyzed with the χ2 test, Fisher exact test, Student t test, and analysis of variance; associations of CMBs with clinical and other MR imaging outcomes were explored with correlation and regression analyses. Because CMB frequency increases with age, prevalence was investigated in participants at least 50 years of age and younger than 50 years. Results Significantly more patients with MS than HCs had CMBs (19.8% vs 7.4%, respectively; P = .01) in the group at least 50 years old. A trend toward greater presence of CMBs was found in patients with MS (P = .016) and patients with CIS who were younger than 50 years (P = .039) compared with HCs. In regression analysis adjusted for age, hypertension, and normalized brain volume, increased number of CMBs was significantly associated with increased physical disability in the MS population (R2 = 0.23, P < .0001). In correlation analysis, increased number of CMBs was significantly associated with deteriorated auditory and verbal learning and memory (P = .006) and visual information processing speed trends (P = .049) in patients with MS. Conclusion Monitoring CMBs may be relevant in patients with MS and CIS at higher risk for developing cognitive and physical disability. © RSNA, 2016 Online supplemental material is available for this article.
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Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Hemorrhage / Multiple Sclerosis Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Humans / Middle aged Language: En Journal: Radiology Year: 2016 Type: Article
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Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Hemorrhage / Multiple Sclerosis Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Humans / Middle aged Language: En Journal: Radiology Year: 2016 Type: Article