Albumin-binding adenoviruses circumvent pre-existing neutralizing antibodies upon systemic delivery.

Rojas, Luis Alfonso; Condezo, Gabriela N; Moreno, Rafael; Fajardo, Carlos Alberto; Arias-Badia, Marcel; San Martín, Carmen; Alemany, Ramon

Rojas, Luis Alfonso; Condezo, Gabriela N; Moreno, Rafael; Fajardo, Carlos Alberto; Arias-Badia, Marcel; San Martín, Carmen; Alemany, Ramon.

Affiliation

Rojas LA; Virotherapy and Gene therapy Group, ProCure Program, Instituto Catalan de Oncología-IDIBELL, L'Hospitalet de Llobregat 08908, Spain.
Condezo GN; Department of Macromolecular Structure, Centro Nacional de Biotecnología (CNB-CSIC), Madrid 28049, Spain.
Moreno R; Virotherapy and Gene therapy Group, ProCure Program, Instituto Catalan de Oncología-IDIBELL, L'Hospitalet de Llobregat 08908, Spain.
Fajardo CA; Virotherapy and Gene therapy Group, ProCure Program, Instituto Catalan de Oncología-IDIBELL, L'Hospitalet de Llobregat 08908, Spain.
Arias-Badia M; Virotherapy and Gene therapy Group, ProCure Program, Instituto Catalan de Oncología-IDIBELL, L'Hospitalet de Llobregat 08908, Spain.
San Martín C; Department of Macromolecular Structure, Centro Nacional de Biotecnología (CNB-CSIC), Madrid 28049, Spain.
Alemany R; Virotherapy and Gene therapy Group, ProCure Program, Instituto Catalan de Oncología-IDIBELL, L'Hospitalet de Llobregat 08908, Spain. Electronic address: ralemany@iconcologia.net.

J Control Release ; 237: 78-88, 2016 09 10.

Article in En | MEDLINE | ID: mdl-27388756

Subject(s)

Adenoviridae/metabolism; Antibodies, Neutralizing/metabolism; Antibodies, Viral/metabolism; Neoplasms/therapy; Oncolytic Viruses/metabolism; Serum Albumin/metabolism; Adenoviridae/immunology; Animals; Antibodies, Neutralizing/immunology; Antibodies, Viral/immunology; Cell Line, Tumor; Female; HEK293 Cells; Humans; Immunization; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasms/immunology; Neoplasms/metabolism; Oncolytic Viruses/immunology; Protein Binding

Key words

Adenovirus; Albumin; Albumin-binding domain; Neutralizing antibodies

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serum Albumin / Adenoviridae / Oncolytic Viruses / Antibodies, Neutralizing / Antibodies, Viral / Neoplasms Limits: Animals / Female / Humans Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2016 Type: Article Affiliation country: Spain

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