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Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage.
Deb, Gauri; Somervaille, Tim C P.
Affiliation
  • Deb G; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
  • Somervaille TCP; Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK. Electronic address: tim.somervaille@cruk.manchester.ac.uk.
Cancer Cell ; 30(1): 5-7, 2016 07 11.
Article in En | MEDLINE | ID: mdl-27411580
ABSTRACT
E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Cell Differentiation Limits: Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2016 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Cell Differentiation Limits: Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2016 Type: Article Affiliation country: United kingdom