Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice.

Sanders, Teresa H; Jaeger, Dieter

Sanders, Teresa H; Jaeger, Dieter.

Affiliation

Sanders TH; Biology Department, Emory University, Atlanta, GA 30322, USA. Electronic address: teresa.hinkle.sanders@gmail.com.
Jaeger D; Biology Department, Emory University, Atlanta, GA 30322, USA.

Neurobiol Dis ; 95: 225-37, 2016 Nov.

Article in En | MEDLINE | ID: mdl-27452483

Subject(s)

Hypokinesia/drug therapy; Movement/drug effects; Neurons/drug effects; Oxidopamine/pharmacology; Subthalamic Nucleus/drug effects; Animals; Deep Brain Stimulation/methods; Disease Models, Animal; Humans; Male; Mice, Inbred C57BL; Motor Cortex/drug effects; Motor Cortex/pathology; Movement/physiology; Neurons/pathology; Optogenetics/methods; Parkinson Disease/pathology; Subthalamic Nucleus/pathology

Key words

DBS; Deep brain stimulation; Local field potential; Motor cortex; Movement analysis; Optogenetics; PAC; Parkinson's disease; Phase-amplitude coupling; Subthalamic nucleus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidopamine / Hypokinesia / Subthalamic Nucleus / Movement / Neurons Limits: Animals / Humans / Male Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2016 Type: Article

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