Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis.

Yu, Jia; Zuo, Teng; Deng, Wenhong; Shi, Qiao; Ma, Peng; Chen, Chen; Zhao, Liang; Zhao, Kailiang; Wang, Weixing

Yu, Jia; Zuo, Teng; Deng, Wenhong; Shi, Qiao; Ma, Peng; Chen, Chen; Zhao, Liang; Zhao, Kailiang; Wang, Weixing.

Affiliation

Yu J; Department of Hepatobilliary & Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Zuo T; Hubei Key Laboratory for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Deng W; Department of Hepatobilliary & Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Shi Q; Hubei Key Laboratory for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Ma P; Department of Hepatobilliary & Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Chen C; Hubei Key Laboratory for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Zhao L; Department of Hepatobilliary & Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Zhao K; Hubei Key Laboratory for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.
Wang W; Department of Hepatobilliary & Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.

BMC Gastroenterol ; 16(1): 81, 2016 Jul 27.

Article in En | MEDLINE | ID: mdl-27465581

Subject(s)

Adrenal Insufficiency/drug therapy; Pancreatitis, Acute Necrotizing/complications; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use; Adrenal Glands/enzymology; Adrenal Glands/pathology; Adrenal Glands/ultrastructure; Adrenal Insufficiency/etiology; Adrenal Insufficiency/pathology; Animals; Apoptosis; Cytokines/metabolism; Disease Models, Animal; Enzyme Activation; Male; NF-kappa B/metabolism; Neutrophil Infiltration; Pancreas/enzymology; Pancreas/pathology; Pancreatitis, Acute Necrotizing/drug therapy; Pancreatitis, Acute Necrotizing/pathology; Poly(ADP-ribose) Polymerases/metabolism; Rats, Wistar

Key words

3-Aminobenzamide; Acute necrotizing pancreatitis; Adrenal injury; Adrenal insufficiency; Apoptosis; Poly(ADP-ribose) polymerase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adrenal Insufficiency / Pancreatitis, Acute Necrotizing / Poly(ADP-ribose) Polymerase Inhibitors Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: BMC Gastroenterol Journal subject: GASTROENTEROLOGIA Year: 2016 Type: Article

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