Exosomes derived from tumor cells genetically modified to express Mycobacterium tuberculosis antigen: a novel vaccine for cancer therapy.

Koyama, Yoshiyuki; Ito, Tomoko; Hasegawa, Aya; Eriguchi, Masazumi; Inaba, Toshio; Ushigusa, Takahiro; Sugiura, Kikuya

Koyama, Yoshiyuki; Ito, Tomoko; Hasegawa, Aya; Eriguchi, Masazumi; Inaba, Toshio; Ushigusa, Takahiro; Sugiura, Kikuya.

Affiliation

Koyama Y; Japan Anti-tuberculosis Association, Shin-Yamanote Hospital, 3-6-1 Suwa-cho, Higashimurayama, Tokyo, 189-0021, Japan. drkoyama@vivid.ocn.ne.jp.
Ito T; Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-oraikita, Izumisano, Osaka, 598-8531, Japan. drkoyama@vivid.ocn.ne.jp.
Hasegawa A; Japan Anti-tuberculosis Association, Shin-Yamanote Hospital, 3-6-1 Suwa-cho, Higashimurayama, Tokyo, 189-0021, Japan.
Eriguchi M; Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-oraikita, Izumisano, Osaka, 598-8531, Japan.
Inaba T; Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-oraikita, Izumisano, Osaka, 598-8531, Japan.
Ushigusa T; Japan Anti-tuberculosis Association, Shin-Yamanote Hospital, 3-6-1 Suwa-cho, Higashimurayama, Tokyo, 189-0021, Japan.
Sugiura K; Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-oraikita, Izumisano, Osaka, 598-8531, Japan.

Biotechnol Lett ; 38(11): 1857-1866, 2016 Nov.

Article in En | MEDLINE | ID: mdl-27484689

Subject(s)

Antigens, Bacterial/genetics; Bacterial Proteins/genetics; Cancer Vaccines/administration & dosage; Exosomes/metabolism; Melanoma, Experimental/drug therapy; Animals; Antigens, Bacterial/immunology; Antigens, Bacterial/metabolism; Antigens, Neoplasm/immunology; Bacterial Proteins/immunology; Bacterial Proteins/metabolism; Cancer Vaccines/genetics; Cancer Vaccines/immunology; Cell Line, Tumor; Exosomes/genetics; Exosomes/immunology; Immunotherapy; Melanoma, Experimental/genetics; Melanoma, Experimental/immunology; Mice; Mycobacterium tuberculosis/genetics; Mycobacterium tuberculosis/immunology; Transfection

Key words

Cancer vaccine; Early secretory antigenic target-6 (ESAT-6); Exogenous danger signal; Exosomes; Mycobacterium tuberculosis antigen; Neoantigens; Neoepitopes

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Melanoma, Experimental / Cancer Vaccines / Exosomes / Antigens, Bacterial Limits: Animals Language: En Journal: Biotechnol Lett Year: 2016 Type: Article Affiliation country: Japan

Search on Google

XML

PubMed Links