Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aß Production and Tau Hyperphosphorylation of the Hippocampus.

Zhang, Zhao-Xu; Zhao, Rui-Ping; Wang, De-Sheng; Li, Yan-Bing

Zhang, Zhao-Xu; Zhao, Rui-Ping; Wang, De-Sheng; Li, Yan-Bing.

Affiliation

Zhang ZX; Department of Neurology, The Shandong Province Qianfoshan Hospital, Jinan, 250000, China. hydzhangzhaoxu@163.com.
Zhao RP; Division of Medical Quality Control, The Shandong Province Qianfoshan Hospital, Jinan, 250000, China.
Wang DS; Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.
Li YB; Department of Neurology, The Shandong Province Qianfoshan Hospital, Jinan, 250000, China. 13605316835@163.com.

Neurochem Res ; 41(11): 3074-3082, 2016 Nov.

Article in En | MEDLINE | ID: mdl-27518086

Subject(s)

Alzheimer Disease/drug therapy; Amyloid beta-Peptides/biosynthesis; Drugs, Chinese Herbal/pharmacology; Hippocampus/drug effects; Neurofibrillary Tangles/drug effects; tau Proteins/metabolism; Aging; Alzheimer Disease/metabolism; Animals; Cyclin-Dependent Kinase 5/metabolism; Disease Models, Animal; Down-Regulation; Hippocampus/metabolism; Male; Mice; Neurofibrillary Tangles/metabolism; Phosphorylation/drug effects

Key words

Alzheimer's disease; BACE1; Cyclin-dependent kinase 5 (CDK5); Fuzhisan (FZS); Tau; ß-Amyloid (Aß)

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Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / Amyloid beta-Peptides / Neurofibrillary Tangles / Tau Proteins / Alzheimer Disease / Hippocampus Limits: Animals Language: En Journal: Neurochem Res Year: 2016 Type: Article Affiliation country: China

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