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Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium.
Margheri, Francesca; Ceruso, Mariangela; Carta, Fabrizio; Laurenzana, Anna; Maggi, Laura; Lazzeri, Simone; Simonini, Gabriele; Annunziato, Francesco; Del Rosso, Mario; Supuran, Claudiu T; Cimaz, Rolando.
Affiliation
  • Margheri F; a Department of Experimental and Clinical Biomedical Sciences , University of Florence , Florence , Italy.
  • Ceruso M; b Neurofarba Department, University of Florence , Florence , Italy.
  • Carta F; b Neurofarba Department, University of Florence , Florence , Italy.
  • Laurenzana A; a Department of Experimental and Clinical Biomedical Sciences , University of Florence , Florence , Italy.
  • Maggi L; c Department of Experimental and Clinical Medicine , University of Florence , Florence , Italy , and.
  • Lazzeri S; d Anna Meyer Children's Hospital and University of Florence , Florence , Italy.
  • Simonini G; b Neurofarba Department, University of Florence , Florence , Italy.
  • Annunziato F; d Anna Meyer Children's Hospital and University of Florence , Florence , Italy.
  • Del Rosso M; c Department of Experimental and Clinical Medicine , University of Florence , Florence , Italy , and.
  • Supuran CT; a Department of Experimental and Clinical Biomedical Sciences , University of Florence , Florence , Italy.
  • Cimaz R; b Neurofarba Department, University of Florence , Florence , Italy.
J Enzyme Inhib Med Chem ; 31(sup4): 60-63, 2016.
Article in En | MEDLINE | ID: mdl-27539792
ABSTRACT
Juvenile idiopathic arthritis (JIA) is the most common form of chronic rheumatic disease affecting children worldwide, with some features similar to adult rheumatoid arthritis (RA). In the present study, we aim at investigating novel markers that will allow in the future for tailored, more personalized treatment strategies. Hence, taking notice of several reports proving the role of local acidosis as a causal link between inflammatory diseases and related pain, and the involvement of several carbonic anhydrases (CA, EC 4.2.1.1) isoforms in articular diseases, we evaluated in JIA patients the expression of these metalloenzymes. We identified that JIA patients show high levels of active CA IX and XII isoforms. Our results represent the first evidence of the identification of these enzymes as potential therapeutic targets and development of novel innovative therapies for arthritis, also considering that the two isoforms are validated antitumor targets.
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Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Juvenile / Synovial Membrane / Carbonic Anhydrases / Carbonic Anhydrase IX Type of study: Prognostic_studies Limits: Adolescent / Child / Child, preschool / Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: Italy
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Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Juvenile / Synovial Membrane / Carbonic Anhydrases / Carbonic Anhydrase IX Type of study: Prognostic_studies Limits: Adolescent / Child / Child, preschool / Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: Italy