Monotherapy with darunavir/ritonavir or lopinavir/ritonavir versus standard antiretroviral therapy: a randomized clinical trial (2pm Study).
New Microbiol
; 39(4): 290-294, 2016 Oct.
Article
in En
| MEDLINE
| ID: mdl-27551725
ABSTRACT
In a multicentre, open-label, clinical trial, 43 patients virologically suppressed while receiving a standard triple antiretroviral therapy were randomized (111) to switch to monotherapy with darunavir/ritonavir (DRV/r-MT arm), monotherapy with lopinavir/ritonavir (LPV/r-MT arm) or to continue on the ongoing regimen (cART arm). The proportion (95% CI) of patients with virological success (Snapshot analysis) at week 48 was 73% (48%-90%) in the DRV/r-MT arm, 69% (42%-88%) in the LPV/r-MT arm and 87% (61%-98%) in the cART arm. Virological failure was detected in only one patient receiving LPV/r-MT. The LPV/r-MT arm showed a modest worsening in lipid profile.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
Ritonavir
/
Lopinavir
/
Darunavir
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
New Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2016
Type:
Article
Affiliation country:
Italy