Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.

Lien, Evan C; Lyssiotis, Costas A; Cantley, Lewis C

Lien, Evan C; Lyssiotis, Costas A; Cantley, Lewis C.

Affiliation

Lien EC; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, EC/CLS-628C, Boston, MA, 02215, USA.
Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, 1150 E. Medical Center Drive, Room 6308, Ann Arbor, MI, 48109, USA.
Cantley LC; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, 1150 E. Medical Center Drive, Room 6308, Ann Arbor, MI, 48109, USA.

Recent Results Cancer Res ; 207: 39-72, 2016.

Article in En | MEDLINE | ID: mdl-27557534

Subject(s)

Neoplasms/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/physiology; TOR Serine-Threonine Kinases/metabolism; Carcinogenesis/pathology; Cell Proliferation/physiology; Humans; Neoplasms/pathology

Key words

Akt; Cancer; Metabolism; PI3K; Signaling; mTOR

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / TOR Serine-Threonine Kinases / Neoplasms Limits: Humans Language: En Journal: Recent Results Cancer Res Year: 2016 Type: Article Affiliation country: United States

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