Identification and inhibition of carbonic anhydrases from nematodes.
J Enzyme Inhib Med Chem
; 31(sup4): 176-184, 2016.
Article
in En
| MEDLINE
| ID: mdl-27557594
ABSTRACT
Carbonic anhydrases (CAs) are metalloenzymes, and classified into the evolutionarily distinct α, ß, γ, δ, ζ, and η classes. α-CAs are present in many living organisms. ß- and γ-CAs are expressed in most prokaryotes and eukaryotes, except for vertebrates. δ- and ζ-CAs are present in phytoplanktons, and η-CAs have been found in Plasmodium spp. Since the identification of α- and ß-CAs in Caenorhabditis elegans, the nematode CAs have been considered as an emerging target in research focused on antiparasitic CA inhibitors. Despite the presence of α-CAs in both helminths and vertebrates, structural studies have revealed different kinetic and inhibition results. Moreover, lack of ß-CAs in vertebrates makes this enzyme as an attractive target for inhibitory studies against helminthic infection. Some CA inhibitors, such as sulfonamides, have been evaluated against nematode CAs. This review article aims to present comprehensive information about the nematode CAs and their inhibitors as potential anthelminthic drugs.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfonamides
/
Carbonic Anhydrase Inhibitors
/
Carbonic Anhydrases
/
Nematoda
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Enzyme Inhib Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2016
Type:
Article
Affiliation country:
Finland